Voyage to the Bottom of the Sea - Season 4 Episode 13 Deadly Amphibians
Overview: Seaview has been sent to the ocean floor by mysterious pressure impacts. Crane, Sharkey, and Kowalski go out in the Flying Sub to investigate. They, too, are sent to the bottom of the sea. Strange creatures (half men-half fish) present themselves and explain that they intend to take over Seaview (who doesn't?) and eventually the world! Don Matheson starred as Mark Wilson in Land of the Giants.